Medicine

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#2426 Perspectives of mesenchymal stem cells in the treatment of inflammatory and degenerative diseases

Abstract: This paper provides a structured approach to investigating the potential of mesenchymal stem cells in treating inflammatory and degenerative diseases, covering key aspects from basic characterization to clinical applications and future prospects. Certains aspects of mesenchymal stem cells (MSC) application are investigated, such as immunomodulatory [...] Load More effects, tissue repair with regeneration capabilities and paracrine signaling analysis. Preclinical studies were performed, including animal models of inflammatory diseases (rheumatoid arthritis, inflammatory bowel disease) and animal models of degenerative diseases (e.g., osteoarthritis, neurodegenerative disorders). Obtained results were used for evaluation of MSC efficacy and safety. Future researchers have a perspective of investigating development of off-the-shelf MSC products.
Keywords: mesenchymal stem cells, inflammatory diseases, degenerative diseases, animal models
Date of publication: December 2025 / Deadline: 21 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: WoS SSCI/SCI Q2

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#2425 Developing medical activities for improving the effectiveness of dynamic monitoring of the health of patients with diabetes and hypertension

Abstract: Dynamic monitoring is an important component of modern medical treatment practices, including diabetes and hypertension treatment. Aim of this paper is proposing organizational strategies to enhance monitoring effectiveness. The authors used mixed-methods approach which included quantitative analysis of patient data and health outcomes, qualitative [...] Load More analysis of interviews with healthcare providers and patients and observational studies of current monitoring practice. Following the established method, the authors analyzed collected data to identify effective monitoring strategies and compared outcomes across different organizational approaches. Results of research propose evaluation metrics for assessing implementation success. Practical novelty of this paper contributes to implementing improved monitoring strategies for healthcare providers, patients, and health systems.
Keywords: diabetes, hypertension, health dynamic monitoring, medical treatment
Date of publication: December 2025 / Deadline: 21 April 2025

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Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: WoS SSCI/SCI Q2

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#2420 Clinical and experimental study of physiological aspects of stress reactions during sinus lifting and dental implantation in elderly patients with systemic diseases

Abstract: This paper presents a comprehensive clinical and experimental study examining the physiological aspects of stress reactions in elderly patients undergoing sinus lifting and dental implantation procedures, particularly those with pre-existing systemic diseases. As the aging population increasingly seeks dental rehabilitation, understanding the stress [...] Load More responses associated with these surgical interventions is crucial for optimizing patient care and outcomes. The study involved a cohort of elderly patients diagnosed with various systemic conditions, who underwent sinus lifting and subsequent dental implants. Physiological parameters, including heart rate variability, cortisol levels, and subjective stress assessments, were monitored preoperatively, intraoperatively, and postoperatively. Our findings indicate that systemic diseases significantly influence stress reactions, with variations observed in physiological responses during the surgical process. The results highlight the need for tailored preoperative assessments and stress management strategies to enhance patient safety and improve recovery trajectories in this vulnerable demographic. Overall, this research underscores the importance of integrating physiological stress evaluation into clinical practice for elderly patients undergoing dental surgeries, fostering a more holistic approach to their care.
Keywords: sinus lifting, dental implantations, stress reactions, dentistry patient care, elderly patients
Date of publication: November 2025 / Deadline: 21 April 2025

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Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: Scopus Q2

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#2415 New global trends in dental implantation systems: medical, social and economic aspects

Abstract: This research aims to explore the latest global trends in dental implantation systems, focusing on how emerging technologies and practices can address health disparities across different populations. The study will examine the medical advancements in dental implants, the social implications of accessibility and acceptance, and the economic factors influencing [...] Load More the adoption of these technologies in various regions. The authors conducted a surveys and interviews to gather data from dental professionals and patients across diverse demographics and performed economic modeling to assess the cost implications of different dental implant systems. The outcomes of this paper provide comprehensive understanding of how new dental implant technologies can contribute to global health equity. In particular, this research proposes practical recommendations to enhance the integration of innovative dental solutions in underserved communities. Theoretical field is contributed with insights into how to make dental implants more accessible and effective, ultimately improving oral health outcomes worldwide.
Keywords: dental implantation, new trends in dentistry, econometrics of dental implantation, social aspects of dental implantation
Date of publication: November 2025 / Deadline: 21 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Medicine, Sociology

Indexing of the journal: Scopus Q1

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#2414 Predictors of skin aging and complex correction system of involutional skin changes

Abstract: Objective of this study is to explore the various predictors of skin aging and to develop a comprehensive system for the correction of involutional changes in the skin. For achieving this goal, the paper utilizes quantitative approach with conducting surveys and skin assessments among diverse demographic groups to collect data on skin condition and [...] Load More potential predictors. Digital imaging technology was utilized to analyze skin changes, and then statistical analysis was applied to identify significant predictors. Findings of this study include identification of key skin aging predictors and validated system for complex correction of involutional changes. Practical novelty of this paper lies in developing a multi-faceted correction system that includes preventive measures (lifestyle changes, skincare routines), therapeutic interventions (topical treatments, procedures) and Educational materials for patients and professionals. Theoretical novelty of the study comprises its contributions to the field of dermatology and skincare with potential implications for clinical practice and future research.
Keywords: skin aging, involutional changes, aging predictors, skin therapeutic interventions
Date of publication: November 2025 / Deadline: 21 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: Scopus Q2

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#25-med Type 1 diabetes mellitus and pregnancy: assessment of glycemic profile variability as the basis of insulin therapy strategy

Abstract: Currently, there is practically no evidence base confirming or refuting the effect of pathological glucose variability, the duration of hyperglycemic and hypoglycemic states on the frequency and severity of pregnancy complications in women with type 1 diabetes mellitus (DM). The research purpose is to develop criteria for assessing the state of carbohydrate [...] Load More metabolism (CM) in pregnant women with type 1 diabetes to determine the insulin therapy strategy and management tactics. The methodology used in the work is based on current approaches to the examination and treatment of patients with type 1 DM during pregnancy. The work was carried out according to the design of a comparative prospective study of the case-control type. The analytical method, empirical methods of observation, comparison, and logical analysis were used; methods for assessing the state of the CM were applied; an assessment of glucose variability, a study of indicators of the hemostasis system, an assessment of the frequency and severity of obstetric complications, as well as the condition of newborns from mothers with type 1 DM on a percentile scale were carried out; the results of using various regimens of insulin therapy for type 1 DM during pregnancy were analyzed; a prognostic model for the development of endothelial damage, the frequency and severity of obstetric complications in women with type 1 DM and the degree of perinatal complications were developed; indicators of the duration of hyperglycemia and the duration of the hypoglycemic state during the day, the degree and duration of glucose variability were studied; the relationship between glucose variability, the duration of hyperglycemic, hypoglycemic state, and endothelial damage, disorders in the hemostasis system in such women during pregnancy were demonstrated; the advantage of a regimen of continuous subcutaneous insulin infusion in achieving euglycemia during the day, reducing glucose variability, reducing the frequency and severity of hypoglycemic episodes, and reducing obstetric and perinatal complications in the examined women was confirmed; the prognostic significance of CM indicators was studied and confirmed; optimal management of pregnancy in women with type 1 DM was developed. Novelty of research: a comprehensive assessment of the parameters of CM in pregnant women with type 1 DM was carried out; the duration of hyperglycemia during the day, the duration of hypoglycemia, and the assessment of glucose variability using estimated coefficients were studied; for the first time, a comparative analysis of CM indicators was carried out in pregnant women with type 1 DM who used the regimen of continuous subcutaneous insulin infusion, and in pregnant women who received multiple insulin injections; the advantage of the regimen of continuous subcutaneous insulin infusion in achieving target glycemic values in pregnant women with type 1 DM, reducing the variability of glucose concentration and the frequency of hypoglycemic episodes when using various functions of the insulin pump was substantiated; it was proven that pathological glucose variability is a predictor of endothelial damage, it leads to disruption in the hemostasis system, reduces the functional state of the kidneys, and increases the frequency and severity of preeclampsia in pregnant women with type 1 DM; positive correlation dependence of pathological glucose variability and duration of hyperglycemic conditions in mother and neonatal complications in newborns from mothers with type 1 DM were revealed.
Keywords: pregnancy; glucose; insulin therapy; complications; type 1 diabetes mellitus; carbohydrate metabolism.
Date of publication: July 2025 / Deadline: 20 April 2025

Journal title: available for those who has paid.

Region of the journal publication: All countries.

Scientific field: Medicine, Endocrinology.

Indexing of the journal: Scopus Q 1+WoS (SCIE/SCI).

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#33 Obesity in working age men: hormonal-metabolic and hemodynamic risk factors for cardiac arrhythmias

Abstract: Obesity (Ob) contributes to the development of a number of cardiovascular risk factors associated with cardiac arrhythmias. Currently, the problem of the prevalence of heart rhythm disturbances and their nature, the relationship of arrhythmias with possible risk factors associated with Ob in patients most at risk of death from cardiovascular diseases [...] Load More – working age men (WAM) with Ob, has not been studied enough. The research purpose is to study the hormonal-metabolic and hemodynamic risk factors for cardiac arrhythmias in WAM with Ob. The design of this study is presented as a cross-sectional, comparative, non-randomized, and descriptive study of three groups of patients: with normal body weight (BW), overweight BW, and obese patients. In the work, clinical (including anthropometric parameters), laboratory (including hormonal blood test), instrumental (24-hour monitoring of the electrocardiogram (ECG)), 24-hour monitoring of blood pressure (BP, echocardiogram) research methods, testing of patients for probability of obstructive sleep apnea syndrome (OSAS) using the Berlin questionnaire and statistical research methods were applied. In the study, it was found that in order to identify the features of the heart rhythm and the presence of risk factors for arrhythmias during the examination of WAM with Ob, it is advisable to include Holter monitoring (HM), 24-hour blood pressure monitoring (24HBPM), assessment of the full lipid spectrum with a mandatory study of high density lipoprotein cholesterol (HDL cholesterol); it is necessary to study the level of adiponectin in men with Ob and the chronic heart failure (CHF) in determining the therapy techniques; if there is arrhythmia in patients with Ob under the age of 50, identified during a standard cardiac examination, including HM, additional studies are required to clarify the presence of coronary heart disease (CHD); a significant positive effect on the heart rhythm in patients with Ob is provided by the prescription of statins with the effects on lipid metabolism. The novelty of the research is: a detailed assessment of the structure of cardiac arrhythmia in WAM with different BW was carried out, a significantly higher frequency of arrhythmias, both supraventricular and ventricular, was established in the presence of Ob with a progressive increase in their frequency as its severity worsens; a significant relationship was evidenced between the incidence of atrial fibrillation and the degree of increase in BW; the association of dyslipidemia with atrial fibrillation and ventricular extrasystole was revealed; it was shown that a low level of HDL cholesterol increases the risk of atrial fibrillation by 3.77, ventricular extrasystole by 2.30 times; no significant effect of the level of glycemia, insulinemia, and insulin resistance on the heart rhythm was found; the possibility of an adverse effect of an increased content of adiponectin on the frequency of ventricular extrasystole was demonstrated; it was shown that the increase in the frequency of supraventricular extrasystole and ventricular extrasystole with age and Ob is due to the presence of CHD, in the absence of which this pattern was not observed; it was found that in patients with Ob, an increased risk of developing atrial fibrillation is due to such features as a change in the daily BP profile of the nondipper type and myocardial remodeling in terms of dilatation of the left ventricle and left atrium, the risk of ventricular extrasystole is due to a change in the daily BP profile of the nondipper type and left ventriclar hypertrophy and left ventriclar diastolic dysfunction, the risk of supraventricular extrasystole is due to the left ventriclar diastolic dysfunction; also a positive effect was shown in the treatment with rosuvastatin to reduce the daily amount of ventricular extrasystole in patients with Ob.
Keywords: obesity; cardiovascular risk; heart rhythm; working age.
Date of publication: July 2025 / Deadline: 20 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: Scopus (Q2); WoS (Science Citation Index Expanded ).

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#32 Metabolic, hormonal and genetic factors in the formation of the obesity phenotype, their significance in the development of kidney failure and the benefits of therapeutic medication

Abstract: The study of the obesity phenotype in working age people with the determination of genetic predictors and the identification of pathogenetic relationships between the components of the cardiorenal continuum with the assessment of the benefits of therapeutic medication in dynamics is an important area of scientific research that is of practical significance [...] Load More for modern health care. The research purpose is to study the input of the main pathogenetic factors in the formation of the obesity phenotype, to determine the relationship of hormonal-metabolic and genetic parameters with markers of renal dysfunction in groups, and to evaluate the effectiveness of therapeutic medication over time. When performing the work, clinical, laboratory, genetic, instrumental, and statistical research methods were applied. The study objects were patients with metabolically healthy obesity (MHO) and metabolically complicated obesity (CO) associated with arterial hypertension (AH), patients with AH without obesity; the referential group included healthy respondents without obesity. In the study, differences in obesity phenotypes were established in terms of parameters of the body composition; the gender feature of the development of leptin resistance was determined; a mathematical module to identify preclinical renal dysfunction in obese patients was developed; the optimal range of body weight loss (BW) from 5 to 15% of the baseline within 6 months, predictors of effective weight loss in patients with obesity and additional criteria for effectiveness were determined; a method for predicting the effectiveness of reducing body weight in obese patients by the index of free leptin was introduced into practice; prognostic markers for effective treatment of obesity in patients with metabolic disorders were developed. The scientific novelty is an expanded characterization of various obesity phenotypes based on complex laboratory and genetic studies; for the first time a comparative assessment of the state of the kidneys in patients with different obesity phenotypes was carried out; a mathematical module was developed to assess the formation of early renal dysfunction in patients with CO; predictors of an effective decrease in BW in patients with obesity were determined; prognostic markers of effective treatment of obesity in patients with metabolic disorders were proposed.
Keywords: metabolism; obesity; kidney failure; renal dysfunction; therapy.
Date of publication: July 2025 / Deadline: 20 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: Scopus (Q2), Web of Science (Science Citation Index Expanded, Q2) IF 3,5.

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#31 Dental implantation in patients with chronic obstructive pulmonary disease

Abstract: At present, with the expansion of indications for dental implantation, the problem of reducing the risk of complications, among the most significant causes of which is the general somatic pathology in the patient, becomes urgent. A significant number of somatic pathology, especially in patients over the age of 40 years old, is chronic obstructive pulmonary [...] Load More disease (COPD). At present, there is no systematic source of information on the dental status of COPD patients undergoing dental implantation. The research purpose is to increase the effectiveness of dental implantation in COPD patients. The study was carried out according to the principles and rules of evidence-based medicine. Clinical and functional methods (laser Doppler flowmetry, optical tissue oximetry), the method of resonant frequency analysis of implant stability, X-ray, and statistical research methods were applied. The object of the study were 43 patients diagnosed with partial loss of teeth and diagnosed with COPD. As a result of the studies on COPD patients after dental implantation, the features of the pathogenesis of osseointegration processes were revealed according to microhemodynamics and oxygenation data; at the stages of preparation and implementation of dental implantation, recommendations were made for antioxidant and anti-osteoporotic therapy in COPD patients; a plan for preoperative preparation and postoperative management of COPD patients during dental implantation was developed. Novelty of the research: for the first time, the clinical and functional features of the condition in the mucous membrane of the alveolar ridge in COPD patients were studied; for the first time a comparative analysis of laboratory data and data of ultrasonic densitometry and X-ray absorptiometry (axial skeleton) before and after osteotropic therapy in these patients was carried out; based on specific, osteotropic, and antioxidant therapy, normalization of mineral metabolism in bone tissue, good osseointegration of dental implants, and restoration of tissue blood flow in COPD patients were achieved.
Keywords: antioxidant therapy; dental implantation; osteotropic therapy; dentistry; chronic obstructive pulmonary disease.
Date of publication: July 2025 / Deadline: 20 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Dentistry.

Indexing of the journal: Scopus (Q2); WoS (Emerging Sources Citation Index).

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#17 Ovulatory function of the ovaries in women with type 1 diabetes mellitus in relation to the carbohydrate metabolism compensation

Abstract: The features of the reproductive system in women with type 1 diabetes mellitus, manifested in a high frequency of ovarian hormonal insufficiency, which is the leading cause of reproductive dysfunction, were studied. Despite the great attention of researchers to the issues of the pathogenesis of hormonal ovarian insufficiency in such women, this problem [...] Load More remains under-analyzed. In this regard, the research purpose is to study the violation of the ovulatory function of the ovaries and the possibility of its recovery in women of reproductive age with type 1 diabetes, depending on the carbohydrate metabolism compensation. In the study, the clinical and laboratory characteristics of the examined women were compiled based on: the results of clinical and laboratory, and hormonal examinations; determination of anti-ovarian antibodies in the blood in the blood serum of patients using enzyme immunoassay; assessment of the degree of compensation for type 1 diabetes by the level of glycemia and the content of glycated hemoglobin A1c in the blood; evaluation of the stage of diabetic nephropathy based on a general urinalysis, urinalysis for proteinuria, a test for microalbuminuria by quantitative and semi-quantitative methods, and functional tests; ophthalmological examination; ultrasound examination of the pelvic organs; statistical processing of the obtained results using the methods of parametric and non-parametric statistics; processing the material with the statistical tools of the Excel 2010 program, a standard software package for applied statistical analysis; methods of descriptive statistics; assessment of differences in the values of quantitative indicators in different groups according to Student’s t-test for independent samples and the parametric Mann-Whitney U-44 test; comparison of frequency and nominal values according to Pearson’s chi-squared test with Yates correction and Fisher’s exact test for small samples; correlation analysis based on the Spearman’s rank correlation coefficient (r). As a result of the study, it was found that 62.2% of women with type 1 diabetes of reproductive age have ovarian insufficiency; it was determined that the frequency of occurrence of ovarian insufficiency correlates with the compensation of metabolic disorders characteristic of diabetes, insulin dose and does not depend on the insulin regimen, and in patients with anovulatory cycles – a significant decrease in the level of FSH and globulin that binds sex steroids, as well as a significant increase in the level of total and free testosterone levels compared to healthy women. It was proved that ovarian insufficiency in women of reproductive age with type 1 diabetes mellitus is associated with the carbohydrate metabolism compensation, the insulin dose, an increase in the level of total and free testosterone, a decrease in sex steroid-binding globulin, an increase in volume and a change in the structure of the ovaries. The possibility of restoring the ovulatory function of the ovaries in 61.8% of women with decompensated diabetes with anovulation or luteal phase deficiency was confirmed when diabetes compensation was achieved. A number of practical recommendations was developed for wide use in the control of women with type 1 diabetes mellitus of reproductive age: to conduct hormone testing and ultrasound examination of the pelvic organs to assess the hormonal function of the ovaries; with ovarian insufficiency, to carry out more careful control of carbohydrate metabolism and optimize insulin therapy; to re-evaluate the hormonal function of the ovaries when compensation for diabetes in women of reproductive age is achieved; to settle the issue of the advisability of hormone replacement therapy for the prevention of menstrual irregularities and proliferative diseases of the reproductive system in women who do not plan pregnancy. The study is the first to demonstrate that the volume of the ovaries, the number of antral follicles in them in patients with type 1 diabetes mellitus are directly dependent on microvascular diabetic complications and the insulin dose. It was found that the level of progesterone in these patients with a preserved menstrual cycle has a significant negative correlation with the level of glycated hemoglobin. It was proved that the ovulatory function of the ovaries in women with decompensated diabetes and ovarian insufficiency can be restored in 61.8% of cases with compensation for type 1 diabetes. It was confirmed that the data on the normal level of anti-ovarian antibodies and the titer of antibodies to ovarian antigens in such women indicate the absence of the significance of autoimmune ovarian damage in the pathogenesis of ovarian failure in type 1 diabetes mellitus.
Keywords: gynaecology; type 1 diabetes mellitus; ovarian insufficiency; carbohydrate metabolism; ovaries.
Date of publication: July 2025 / Deadline: 20 April 2025

Journal title: available for those who has paid.

Region of the journal publication: Europe.

Scientific field: Medicine.

Indexing of the journal: Scopus (Q2); WoS (Science Citation Index Expanded) IF 3.5.

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