Abstract:
The problem of metabolic syndrome in the modern world has turned into a global epidemic, affecting millions of people. It poses a threat to public health due to the risk of related diseases and pathologies. At the same time, the issue of finding effective treatment methods, especially obesity, remains open. The purpose of this research was to substantiate
[...] Load More the biological, physiological, pathophysiological, and pharmacological aspects of obestatin action for the body's vital activity in the norm and pathology. The basis for identifying the peculiarities was the research that demonstrated the pathogenetic connection and frequent combination of food behavior disorders, essential hypertension, insulin resistance, and lipid metabolism disorders caused by the pathology of the ghrelin-obestatin system. The article analyzes various causes and features of gastrointestinal diseases (diseases of the GI tract). The factors of eating disorder and modern methods of its regulation through endogenous regulators of appetite and body weight have been summarized. Through the inductive generalization method, the peculiarities of ghrelin and obestatin ratio in pathological obesity and among healthy people have been argued. The characteristics of the physiological activity of food hormones in adipogenesis have been generalized. It has been substantiated that obestatin is, as well as ghrelin, regulating hormone in adipocyte metabolism and the transition of pre-adipocytes to adipocytes. Besides, it determines the activity of adipogenesis to a greater degree. This fact suggests that the correct regulation of the obestatin level can accelerate the process of correction of pathologies of the GI tract. Through a literature review, the interaction between body mass index, blood glucose, insulin, and leptin levels and the content of obestatin in the blood has been assessed. The role of obestatin in nutrition regulation has been substantiated. The research also revealed the peculiarities of anorexigenic effects of obestatin, which primarily imply the central action mechanisms, based on the analysis of the modern scientific literature. Its ability to pass the blood-brain barrier (BBB) was also considered, which made it possible to conclude about the ambiguity of the passage mechanisms. Based on the above study, it has been revealed that the data on the central effects of obestatin in the norm and pathology, as well as the assessment of its possible application in clinical practice, are very fragmentary and contradictory. The revealed problems can serve as a basis for the determination of promising scientific research in the field of hormone therapy of cardiometabolic syndrome.
Keywords: cardiometabolic syndrome, obestatin, gastrointestinal tract, pathology, ghrelin, food behavior.
Journal title: available for those who has paid.
Region of the journal publication: Europe.
Scientific field: Medicine.
Indexing of the journal: Scopus (Q1-2); WoS (Science Citation Index Expanded).